Ultrasound-assisted conversion of toxic beta-asarone into nontoxic bioactive phenylpropanoid: Isoacoramone, a metabolite of Piper marginatum and Acorus tararinowii
IR@IHBT: CSIR-Institute of Himalayan Bioresource Technology, Palampur
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| Title |
Ultrasound-assisted conversion of toxic beta-asarone into nontoxic bioactive phenylpropanoid: Isoacoramone, a metabolite of Piper marginatum and Acorus tararinowii
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| Creator |
Sinha, Arun K
Joshi, B P Sharma, A Goel, H C Prasad, J |
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| Subject |
Natural Product Chemistry
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| Description |
Ultrasound-assisted synthesis of bioactive isoacoramone ( 1), a metabolite of Piper marginatum and Acorus tararinowii, has been achieved by oxidation of toxic beta-asarone ( 2) with potassium permanganate/copper sulphate/alumina into asaronaldehyde ( 3) followed by treatment with ethylmagnesium iodide to provide 1-(2,4,5-trimethoxy) phenyl-1-propanol (4) which upon further oxidation with potassium permanganate/ copper sulphate afforded 1 in 64% yield (overall 32%). Toxicological evaluation of 1 reveals it to be nontoxic up to 60 mg/kg b. w.
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| Publisher |
Taylor & Francis Ltd, 4 Park Square, Milton Park, Abingdon OX14 4RN, Oxon, England
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| Date |
2004
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://ihbt.csircentral.net/408/1/156_2004_Ultrasound.pdf
Sinha, Arun K and Joshi, B P and Sharma, A and Goel, H C and Prasad, J (2004) Ultrasound-assisted conversion of toxic beta-asarone into nontoxic bioactive phenylpropanoid: Isoacoramone, a metabolite of Piper marginatum and Acorus tararinowii. Natural Product Research, 18 (3). pp. 219-223. ISSN 1478-6419 |
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| Relation |
http://ihbt.csircentral.net/408/
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