Microwave-assisted minutes synthesis of bioactive phenylbutanoids occurring in Zingiber cassumunar
IR@IHBT: CSIR-Institute of Himalayan Bioresource Technology, Palampur
View Archive Info| Field | Value | |
| Title |
Microwave-assisted minutes synthesis of bioactive phenylbutanoids occurring in Zingiber cassumunar
|
|
| Creator |
Joshi, B P
Singh, N P Sharma, A Sinha, Arun K |
|
| Subject |
Natural Product Chemistry
|
|
| Description |
Microwave-assisted condensation of benzaldehyde (3a,b) with acetone in aqueous sodium hydroxide adsorbed on basic alumina provides phenylbutenone (4a-4b) in 68-71% yield within 4 min, which upon further reduction with sodium borohydride and basic alumina gives phenylbutenol (5a,b) in 91-94% yield within 2 min. Dehydration of 5 with anhydrous copper (H) sulfate gives phenylbutadiene (1a,b), a metabolite of Zingiber cassumunar, within 3 min in 42-48% yield, respectively. All the steps involve environmental friendly solvents and reagents, mild reaction conditions, and overall formation of product 1a,b from 3a,b in 34-38% yield within 9 min under microwave irradiation.
|
|
| Publisher |
Kluwer Academic/Plenum Publishers, 233 Spring ST, New York, NY 10013
|
|
| Date |
2005
|
|
| Type |
Article
PeerReviewed |
|
| Format |
application/pdf
|
|
| Identifier |
http://ihbt.csircentral.net/456/1/177_2005_Microwave.pdf
Joshi, B P and Singh, N P and Sharma, A and Sinha, Arun K (2005) Microwave-assisted minutes synthesis of bioactive phenylbutanoids occurring in Zingiber cassumunar. Chemistry of Natural Compounds, 41 (4). pp. 370-373. ISSN 0009-3130 |
|
| Relation |
http://ihbt.csircentral.net/456/
|
|