RNA Specific Molecules: Cytotoxic Plant Alkaloid Palmatine Binds Strongly to Poly(A)
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
RNA Specific Molecules: Cytotoxic Plant Alkaloid Palmatine
Binds Strongly to Poly(A)
|
|
| Creator |
Giri, Prabal
Hossain, Maidul Kumar, G Suresh |
|
| Subject |
Chemistry
|
|
| Description |
Abstract—The cytotoxic plant alkaloid palmatine was found to bind strongly by partial intercalation to single stranded poly(A) structure with binding affinity (Ka) of (8.36 ± 0.26) · 105 M�1. The binding of palmatine was characterized to be exothermic and enthalpy driven with one palmatine for every two adenine residues. On the other hand, the binding to the double stranded poly(A)
has been found to be significantly weak. This study identifies poly(A) as a potential bio-target for the alkaloid palmatine and its use as a lead compound in antitumor drug screening.
|
|
| Date |
2006
|
|
| Type |
Article
PeerReviewed |
|
| Format |
application/pdf
|
|
| Identifier |
http://www.eprints.iicb.res.in/1116/1/BIOORGANIC_%26_MEDICINAL_CHEMISTRY_LETTERS__Volume_16___Issue_9___Pages_2364%2D2368___[94].pdf
Giri, Prabal and Hossain, Maidul and Kumar, G Suresh (2006) RNA Specific Molecules: Cytotoxic Plant Alkaloid Palmatine Binds Strongly to Poly(A). Bioorganic & Medicinal Chemistry Letters, 16 (9). pp. 2364-2368. |
|
| Relation |
http://dx.doi.org/10.1016/j.bmcl.2006.01.124
http://www.eprints.iicb.res.in/1116/ |
|