Procollagen Synthesis is Increased in Hypothyroid Rat Ovary by a Parallel and Compensatory Pathway
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Procollagen Synthesis is Increased in Hypothyroid Rat Ovary by a Parallel and Compensatory Pathway
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| Creator |
Saha, Samir Kumar
Ghosh, Pamela Bhattacharya, Samir Roy, Sib Sankar |
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| Subject |
Cell Biology & Physiology
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| Description |
Collagen biosynthesis is a multistep process that
starts with the transcription and translation of the
individual collagen gene. It is characterized by the
presence of a large number of co- and posttranslational
modifications. Hydroxylysine is found only in
animal proteins and mostly in collagens. Procollagen
lysyl hydroxylation is the first step in collagen
biosynthetic pathway and lysyl hydroxylases (Plod
isoforms) are responsible for this enzymatic process.
Previously we showed the down regulation of Plod
isoforms in hypothyroid ovary. As hypothyroidism is a
stress for normal animals, we wanted to explore
whether any compensatory pathway exists to balance
the reduced lysyl hydroxylation of collagen in
hypothyroid rat ovary. In this report we have shown
that procollagen I and III are increased in hypothyroid
condition and subsequently decreased upon T3 addback.
Heat Shock Protein-47 is a collagen-specific
molecular chaperone and its existence in ovary has
been documented. The genes encoding HSP-47,prolyl-4-hydroxylase-α and -β (P4H- α and - β) are
increased in hypothyroid condition. Down regulation
of lysyl hydroxylase in hypothyroid condition results
less collagen formation. At the same time over
production of procollagens, HSP-47 and P4H is very
significant as they may compensate the damage
whatsoever caused due to hypothyroidism in ovarian
tissue.
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| Date |
2007
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1122/1/CELLULAR_PHYSIOLOGY_AND_BIOCHEMISTRY__19_(5%2D6_)_313%2D322;2007[139].pdf
Saha, Samir Kumar and Ghosh, Pamela and Bhattacharya, Samir and Roy, Sib Sankar (2007) Procollagen Synthesis is Increased in Hypothyroid Rat Ovary by a Parallel and Compensatory Pathway. Cellular Physiology and Biochemistry, 19 (5-6). pp. 313-322. |
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| Relation |
http://dx.doi.org/10.1159/000100650
http://www.eprints.iicb.res.in/1122/ |
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