Comparative Codon and Amino Acid Composition Analysis of Tritryps-Conspicuous Features of Leishmania Major
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Comparative Codon and Amino Acid Composition Analysis
of Tritryps-Conspicuous Features of Leishmania Major
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| Creator |
Chanda, Ipsita
Pan, Archana Saha, Sanjoy Kumar Dutta, Chitra |
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| Subject |
Structural Biology & Bioinformatics
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| Description |
Comparative analyses of codon/amino acid usage in
Leishmania major, Trypanosoma brucei and Trypanosoma cruzi
reveal that gene expressivity and GC-bias play key roles in shaping the gene composition of all three parasites, and protein composition of L. major only. In T. brucei and T. cruzi, the major contributors to the variation in protein composition are hydropathy and/or aromaticity. Principle of Cost Minimization is followed by T. brucei, disregarded by T. cruzi and opposed by L. major. Slowly evolving highly expressed gene-products of L. major bear signatures of relatively AT-rich ancestor, while faster evolution under GC-bias has characterized the lowly expressed genes of the species by higher GC12-conten.
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| Date |
2007
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1127/1/FEBS_LETTERS__581_(30)_5751%2D5758;2007[3].pdf
Chanda, Ipsita and Pan, Archana and Saha, Sanjoy Kumar and Dutta, Chitra (2007) Comparative Codon and Amino Acid Composition Analysis of Tritryps-Conspicuous Features of Leishmania Major. FEBS Letters, 581 (30). pp. 5751-5758. |
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| Relation |
http://dx.doi.org/10.1016/j.febslet.2007.11.041
http://www.eprints.iicb.res.in/1127/ |
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