CNS and Anticonvulsant Activity of a Non-Protein Toxin (KC-MMTx) Isolated From King Cobra (Ophiophagus hannah) Venom
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
CNS and Anticonvulsant Activity of a Non-Protein Toxin
(KC-MMTx) Isolated From King Cobra (Ophiophagus hannah) Venom
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| Creator |
Saha, A
Gomes, A Chakravarty, A K Biswas, A K Giri, B Dasgupta, S C Gomes, Aparna |
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| Subject |
Drug Development/Diagnostics & Biotechnology
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| Description |
In the present study, King Cobra (Ophiophagus hannah) venom was subjected to TLC followed by column
chromatography/HPLC to isolate and purify a non-protein toxin designated as KC-MMTx. 1H NMR, IR and EIMS studies
showed KC-MMTx likely to be a 282 D unsaturated aliphatic acid having molecular formula C18H34O2. The minimum lethal
dose of KC-MMTx was 200 mg/kg (i.v.) and 350 mg/kg (i.p.) in Swiss albino male mice. It significantly increased
pentobarbitone induced sleeping time and significantly decreased the body temperature of male albino mice. It provided
protection against amphetamine aggregate toxicity in mice but failed to protect amphetamine stereotypy in male albino rats.
KC-MMTx provided significant protection against drug (strychnine, pentylenetetrazole, yohimbine) induced convulsions in
male albino mice. It increased serum NaC and decreased serum Ca2C significantly in male mice. MAO activity and brain
neurotransmitter levels in male mice were altered significantly. Further detailed study is warranted on the CNS, anticonvulsant
potential of KC-MMTx, which may lead to the development of newer therapeutic tools in the near future.
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| Date |
2006
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1128/1/TOXICON__Volume_47___Issue_3___Pages_296%2D303___[120].pdf
Saha, A and Gomes, A and Chakravarty, A K and Biswas, A K and Giri, B and Dasgupta, S C and Gomes, Aparna (2006) CNS and Anticonvulsant Activity of a Non-Protein Toxin (KC-MMTx) Isolated From King Cobra (Ophiophagus hannah) Venom. Toxicon, 47 (3). pp. 296-303. |
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| Relation |
http://dx.doi.org/10.1016/j.toxicon.2005.11.006
http://www.eprints.iicb.res.in/1128/ |
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