Statistical Modeling of Ultrastructural Features of Murine Dermal Collagen under Chronic Low-dose Whole body X-Irradiation.
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Statistical Modeling of Ultrastructural Features of Murine Dermal Collagen under Chronic Low-dose Whole body X-Irradiation.
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| Creator |
Chatterjee, Jyotirmoy
Mukherjee, Anirban Mukherjee, Kanchan Dutta, Pranab K Chaudhuri, Keya |
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| Subject |
Molecular & Human Genetics
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| Description |
The present study investigated the changes in ultrastructural
features of dermal collagen fibrils of mice following
exposure to different cumulative chronic low-dose X-irradiation
through digital image analysis-based statistical modeling. Pubertal
mice were X-irradiated and dorsal skin biopsies were collected
and processed for transmission electron microscopic
(TEM) analysis. TEM features of collagen fibrils showed alteration
in the cross-sectional area, population density and in the
axial periodic pattern of light and dark bands. The mathematical
analysis of histogram data from TEM images revealed some
adaptive behavior in collagen structures of the X-irradiated
group. This finding indicated that exposure to chronic low-dose
X-radiation induced an altered steady state with adaptive variation
in dermal collagen fibrils in irradiated mice.
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| Date |
2007
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1130/1/FEBS_LETTERS__581(_26)_5034%2D5042;2007[24].pdf
Chatterjee, Jyotirmoy and Mukherjee, Anirban and Mukherjee, Kanchan and Dutta, Pranab K and Chaudhuri, Keya (2007) Statistical Modeling of Ultrastructural Features of Murine Dermal Collagen under Chronic Low-dose Whole body X-Irradiation. FEBS Letters, 581 (26). pp. 5034-5042. |
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| Relation |
http://dx.doi.org/10.1016/j.febslet.2007.09.041
http://www.eprints.iicb.res.in/1130/ |
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