Role of an Estrogen-Upregulated 64.0-kDa Uterine Fluid Glycoprotein in Improving Fertility in Women
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Role of an Estrogen-Upregulated 64.0-kDa Uterine
Fluid Glycoprotein in Improving Fertility in Women
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| Creator |
Das, Tuhin
Chattopadhyay, Ratna Ghosh, Sanghamitra Goswami,, Sourendrakanta Chattopadhyay, Dhrubajyoti Chakravarty, Baidyanath Kabir, S N |
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| Subject |
Cell Biology & Physiology
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| Description |
To evaluate the significance of an estrogen-upregulated 64.0-kDa human uterine fluid (hUF) glycoprotein
in relation to promotion of fertility.
Prospective study.
Department of Assisted Reproductive Biology Unit, Institute of Reproductive Medicine, Kolkata. India.
Sixty-three women with unexplained infertility having normal ovulatory cycle with normal endocrine
profile and 18 parous women.
Women either received no stimulation (n � 35) or were stimulated with clomiphene citrate (CC)
alone (100 mg/day from day 3 to day 7; n � 56) or in combination with pure FSH (75 IU on day 3 and day 8;
n � 54) and were subjected to IUI. Parous women (n � 18) receiving no treatment served as control and were
followed-up for spontaneous ovulation.
Main Outcome Measure(s): Uterine fluid protein profile, relative intensity of 64.0-kDa protein, number of mature
follicles, endometrial thickness, and pregnancy.
Expression of the 64.0-kDa protein exhibited positive correlation with prevailing estradiol levels, but
the degree of the protein response to estrogen was comparatively blunted in the CC-incorporated cycles.
Endometrial thickness and pregnancy outcomes correlated positively with the expression of the protein.
The 64.0-kDa hUF protein perhaps plays a role in endometrial receptivity to support pregnancy.
Failure of pregnancy despite documented ovulation in CC-stimulated cycles may be due to its attenuating effects
on expression of the protein. (Fertil Steril� 2007;87:343–50. ©2007 by American Society for Reproductive
Medicine.)
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| Date |
2007
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1133/1/FERTILITY_AND_STERILITY__87(_2)_343%2D350_;2007[113].pdf
Das, Tuhin and Chattopadhyay, Ratna and Ghosh, Sanghamitra and Goswami,, Sourendrakanta and Chattopadhyay, Dhrubajyoti and Chakravarty, Baidyanath and Kabir, S N (2007) Role of an Estrogen-Upregulated 64.0-kDa Uterine Fluid Glycoprotein in Improving Fertility in Women. Fertility and Sterility, 87 (2). pp. 343-350. |
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| Relation |
http://dx.doi.org/10.1016/j.fertnstert.2006.07.1500
http://www.eprints.iicb.res.in/1133/ |
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