Allelic Imbalance at Chromosome 11 in Head and Neck Squamous Cell Carcinoma in an Indian Patient Population
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Allelic Imbalance at Chromosome 11 in Head and Neck
Squamous Cell Carcinoma in an Indian Patient Population
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| Creator |
Mondal, G
Tripathi, A Bhattacharya, N Sikdar, N Roy, A Sengupta, A Roy, B Panda, C K Roychoudhury, Susanta |
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| Subject |
Molecular & Human Genetics
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| Description |
Head and neck squamous cell carcinoma (HNSCC) is the
sixth most common human cancer in all parts of the
world, and it has been estimated that there are around
400 000 new cases each year worldwide.1 It accounts for about
30–40% of all cancer types in India and in the subcontinent.2
Epidemiological studies have linked chronic exposure to
tobacco, betel nut leaf quid, alcohol, and some environmental
factors to the occurrence of HNSCC,3 and the characteristic
molecular genetic events associated with the initiation and
progression of HNSCC are beginning to be understood. The
karyotypes of HNSCC tumours are complex, often near
triploid, and there are multiple numerical and structural
abnormalities, including deletions, balanced and unbalanced
translocations, isochromosomes, dicentric chromosomes, and
homogeneously staining regions.4 Classic cytogenetic analysis
of HNSCC tumours has identified a gradual increase in chromosomal
aberrations from premalignant to malignant
lesions.5 In other studies, consistent chromosomal deletions
and amplifications in several chromosome arms have been
reported.6 In addition, centromeric breakage in several
chromosomes has been shown to be important for the development
of HNSCC.7
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| Date |
2003
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1191/1/45_JCPMP_Free_2003.pdf
Mondal, G and Tripathi, A and Bhattacharya, N and Sikdar, N and Roy, A and Sengupta, A and Roy, B and Panda, C K and Roychoudhury, Susanta (2003) Allelic Imbalance at Chromosome 11 in Head and Neck Squamous Cell Carcinoma in an Indian Patient Population. Journal Of Clinical Pathology, 56 (7). pp. 512-518. |
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| Relation |
http://dx.doi.org/10.1136/jcp.56.7.512
http://www.eprints.iicb.res.in/1191/ |
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