MICROWAVE-ASSISTED MINUTES SYNTHESIS OF BIOACTIVE PHENYLBUTANOIDS OCCURRING IN Zingiber cassumunar
IR@IHBT: CSIR-Institute of Himalayan Bioresource Technology, Palampur
View Archive Info| Field | Value | |
| Title |
MICROWAVE-ASSISTED MINUTES SYNTHESIS OF BIOACTIVE
PHENYLBUTANOIDS OCCURRING IN Zingiber cassumunar
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| Creator |
Joshi, B P
Singh, N P Sharma, A Sinha, Arun K |
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| Subject |
Natural Product Chemistry
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| Description |
Microwave-assisted condensation of benzaldehyde (3a,b) with acetone in aqueous sodium hydroxide adsorbed
on basic alumina provides phenylbutenone (4a–4b) in 68–71% yield within 4 min, which upon further
reduction with sodium borohydride and basic alumina gives phenylbutenol (5a,b) in 91–94% yield within 2
min. Dehydration of 5 with anhydrous copper (II) sulfate gives phenylbutadiene (1a,b), a metabolite of
Zingiber cassumunar, within 3 min in 42–48% yield, respectively. All the steps involve environmental friendly
solvents and reagents, mild reaction conditions, and overall formation of product 1a,b from 3a,b in 34–38%
yield within 9 min under microwave irradiation.
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| Date |
2005
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://ihbt.csircentral.net/492/1/177_2005_Microwave.pdf
Joshi, B P and Singh, N P and Sharma, A and Sinha, Arun K (2005) MICROWAVE-ASSISTED MINUTES SYNTHESIS OF BIOACTIVE PHENYLBUTANOIDS OCCURRING IN Zingiber cassumunar. Chemistry of Natural Compounds, 41 (4). pp. 370-373. |
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| Relation |
http://ihbt.csircentral.net/492/
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