cx,-Antittypsin: A Possible Tool for Diagnosis of Cervical Cancer
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
cx,-Antittypsin: A Possible Tool for Diagnosis of Cervical Cancer
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| Creator |
Bhattacharya, Jharna
Chaudhuri, Lalima |
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| Subject |
Cell Biology & Physiology
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| Description |
cw,-Antitrypsin (a,-AT) is a major serine protease inhibitor present in plasma
(1). It inhibits trypsin, chymotrypsin, collagenase, and elastase activity by formation
of a stable inactive complex with the enzyme (2).
It is well established that the proteolytic activity is associated with neoplastic
growth (3-6) and the active neutral protease produced by the malignant cells
leaks out in the culture media (7,8). If this occurs in vim, the protease may
enter into the general circulation. Under such conditions, serum proteinase activities
in various types of cancer may be controlled by the presence of protease
inhibitors in the serum. Breiger and Trebing (9) reported increased levels of
trypsin inhibitors in some diseases. The serum al-AT values in patients suffering
from hepatocellular carcinomas (IO) and different types of malignancies (11) have
been shown to be significanly increased compared with the (w,-AT values of
normal subjects.
In this paper, quantitation of al-AT has been done both by measurement of
its trypsin inhibitory activity and immunodiffusion to evaluate its importance in
relation to cervical cancer. We suggest that estimation of (r,-AT could be utilized
for the diagnosis of neoplastic disease of cervix.
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| Date |
1990
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1213/1/BIOCHEMICAL_MEDICINE_AND_METABOLIC_BIOLOGY__43_(3)243%2D245;1990[34].pdf
Bhattacharya, Jharna and Chaudhuri, Lalima (1990) cx,-Antittypsin: A Possible Tool for Diagnosis of Cervical Cancer. Biochemical Medicine and Metabolic Biology, 43 (3). pp. 243-245. |
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| Relation |
http://dx.doi.org/10.1016/0885-4505(90)90030-5
http://www.eprints.iicb.res.in/1213/ |
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