Modulation of P-glycoprotein ATPase activity by some phytoconstituents
IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu
View Archive Info| Field | Value | |
| Title |
Modulation of P-glycoprotein ATPase activity by some phytoconstituents
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| Creator |
Najar, I. A.
Sachin, B. S. Sharma, S. C. Satti, N. K. Suri, K. A. Johri, R. K. |
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| Subject |
Chemical Sciences
Pharmacological Sciences |
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| Description |
In the present investigation 16 phytoconstituents, which are active moieties found in several medicinal herbs,
have been evaluated for their P-glycoprotein (P-gp) stimulation/inhibition profi les using a P-gp-dependent
ATPase assay in rat jejunal membrane (in vitro). Acteoside, agnuside, catechin, chlorogenic acid, picroside -II
and santonin showed an inhibitory effect. Negundoside, picroside -I and oleanolic acid caused a stimulatory
effect. Andrographolide, apocyanin, berberine,glycyrrhizin, magniferin and piperine produced a biphasic response (stimulation at low concentration and inhibition at high concentration). The results suggested that a possible interaction of these phytoconstituents at the level of P-gp, could be an important parameter in determining
their role in several key pharmacodynamic events.
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| Date |
2010
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://iiim.csircentral.net/293/1/10.1002ptr.2951.pdf
Najar, I. A. and Sachin, B. S. and Sharma, S. C. and Satti, N. K. and Suri, K. A. and Johri, R. K. (2010) Modulation of P-glycoprotein ATPase activity by some phytoconstituents. Phytotherapy Research, 24 (3). pp. 454-458. ISSN 0951418X |
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| Relation |
http://dx.doi.org/10.1002/ptr.2951
http://iiim.csircentral.net/293/ |
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