Saponins as novel TNF-α inhibitors: isolation of saponins and a nor-pseudoguaianolide from Parthenium hysterophorus
IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu
View Archive Info| Field | Value | |
| Title |
Saponins as novel TNF-α inhibitors: isolation of saponins and a nor-pseudoguaianolide from Parthenium hysterophorus
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| Creator |
Shah, Bhahwal Ali
Chib, Renu Gupta, Pankaj Sethi, Vijay Kumar Koul, Surrinder Andotra, Samar Singh Nargotra, Amit Sharma, Sujata Pandey, Anjali Bani, Sarang Purnima, Basant Taneja, Subhash Chandra |
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| Subject |
Chemical Sciences
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| Description |
Two novel saponins and a 13-nor-pseudoguaianolide designated as hysterolactone were isolated from Parthenium hysterophorus. The two saponins were found to be potent inhibitors of TNF-a. Their mode of inhibition was studied through molecular modeling. The wet lab results were in concordance with the data obtained from docking experiments.
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| Date |
2009
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://iiim.csircentral.net/335/1/10.1039b902041a.pdf
Shah, Bhahwal Ali and Chib, Renu and Gupta, Pankaj and Sethi, Vijay Kumar and Koul, Surrinder and Andotra, Samar Singh and Nargotra, Amit and Sharma, Sujata and Pandey, Anjali and Bani, Sarang and Purnima, Basant and Taneja, Subhash Chandra (2009) Saponins as novel TNF-α inhibitors: isolation of saponins and a nor-pseudoguaianolide from Parthenium hysterophorus. Organic & Biomolecular Chemistry, 7 (16). p. 3230. ISSN 1477-0520 |
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| Relation |
http://dx.doi.org/10.1039/b902041a
http://iiim.csircentral.net/335/ |
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