Piperine analogs as potent Staphylococcus aureus NorA efflux pump inhibitors
IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu
View Archive Info| Field | Value | |
| Title |
Piperine analogs as potent Staphylococcus aureus NorA efflux pump inhibitors
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| Creator |
Sangwan, Payare L.
Koul, Jawahir L. Koul, Surrinder Reddy, Mallepally V. Thota, Niranjan Khan, Inshad A. Kumar, Ashwani Kalia, Nitin P. Qazi, Ghulam N. |
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| Subject |
Chemical Sciences
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| Description |
Based on our recent findings that piperine is a potent Staphylococcus aureus NorA efflux pump inhibitor(EPI), 38 piperine analogs were synthesized and bioevaluated for their EPI activity. Twenty-five of them were found active with potentiating activity equivalent or more than known EPIs like reserpine, carsonic acid and verapamil. The inhibitory mechanism of the compounds was confirmed by efflux inhibition assay using ethidium bromide as NorA substrate. The present communication describes the synthesis,bioevaluation and structure related activity of these efflux pump inhibitors.
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| Date |
2008
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://iiim.csircentral.net/309/1/10.1016j.bmc.2008.09.042.pdf
Sangwan, Payare L. and Koul, Jawahir L. and Koul, Surrinder and Reddy, Mallepally V. and Thota, Niranjan and Khan, Inshad A. and Kumar, Ashwani and Kalia, Nitin P. and Qazi, Ghulam N. (2008) Piperine analogs as potent Staphylococcus aureus NorA efflux pump inhibitors. Bioorganic & Medicinal Chemistry, 16 (22). pp. 9847-9857. ISSN 09680896 |
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| Relation |
http://dx.doi.org/10.1016/j.bmc.2008.09.042
http://iiim.csircentral.net/309/ |
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