Regio-selective acylation of biologically important iridoid glycosides by Candida antarctica lipase
IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu
View Archive Info| Field | Value | |
| Title |
Regio-selective acylation of biologically important iridoid glycosides by Candida antarctica lipase
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| Creator |
Singh, Parvinder Pal
Qazi, Naveed Ahmed Shafi, Syed Reddy, D. Mahendhar Banday, Abid H. Reddy, P. Bhaskar Suri, K.A. Gupta, B.D. Satti, N.K. Wakhloo, Basant P. Kumar, H.M. Sampath Qazi, G.N. |
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| Subject |
Chemical Sciences
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| Description |
Lipase catalyzed regio-selective acylation of five iridoid glycosides viz., picroside I&II, catalpol, agnuside and negundoside in the presence of various acyl donors such as vinyl acetate and p-nitrophenyl alkanoates was studied. The regio-selectivity of enzymatic acylation and yieldswere found to vary amongst different substrates. Monoacylated products were isolated with all the substrates under scrutiny indicating high regio-selective nature of such transformations. A series of acyl esters of picroside-I, picroside-II, catalpol, agnuside and negundoside have been synthesized by this enzymatic trans-esterification methodology.
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| Date |
2009
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://iiim.csircentral.net/331/1/10.1016j.molcatb.2008.04.005.pdf
Singh, Parvinder Pal and Qazi, Naveed Ahmed and Shafi, Syed and Reddy, D. Mahendhar and Banday, Abid H. and Reddy, P. Bhaskar and Suri, K.A. and Gupta, B.D. and Satti, N.K. and Wakhloo, Basant P. and Kumar, H.M. Sampath and Qazi, G.N. (2009) Regio-selective acylation of biologically important iridoid glycosides by Candida antarctica lipase. Journal of Molecular Catalysis B: Enzymatic, 56 (1). pp. 46-54. ISSN 13811177 |
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| Relation |
http://dx.doi.org/10.1016/j.molcatb.2008.04.005
http://iiim.csircentral.net/331/ |
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