Immunomodulatory Stimulation of an Invertebrate Circulatory Lectin by its Haptenic Molecules of Pathogenic Origin
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Immunomodulatory Stimulation of an Invertebrate Circulatory Lectin by its Haptenic Molecules of Pathogenic Origin
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| Creator |
Basu Sarbadhikary, Sujata
Bhadra, Ranjan |
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| Subject |
Infectious Diseases and Immunology
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| Description |
2-keto-3-deoxy octonate and I~-
glycerophosphate two important bacterial cell
wall constituent molecules, haptenic in nature
to an invertebrate (crab) circulatory lectin, carcinoscorpin,
gave lectin induction after immunization
of the crab, Carcinoscorpius rotundacauda.
With the exception of erythrocyte, no
other sialoglycoconjugate-containing substances
(mucin, fetuin) sialodisaccharide
O-[N-acetylneuraminyl-(2 ---> 6)2-acetamido-2-
deoxy galactitol] and free sialic acid were effective
in lectin induction. This induction of
circulatory lectin failed to appear when, concanavalin
A, epinephrine, cytochalasin B,
methyl-o~-I>mannoside and bovine serum albumin
were used for immunization. But mechanical
injury to crabs were extremely effective
in such lectin induction by live crabs. LPS
is lethal if used for immunization. The immunoregulatory
induction of the circulatory lectin
by pathogen-originated cell wall constituent
molecules and mechanical injury may be considered
as a humoral immune response.
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| Date |
1990
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1222/1/DEVELOPMENTAL_AND_COMPARATIVE_IMMUNOLOGY__14(_1)___31%2D38__;1990[6].pdf
Basu Sarbadhikary, Sujata and Bhadra, Ranjan (1990) Immunomodulatory Stimulation of an Invertebrate Circulatory Lectin by its Haptenic Molecules of Pathogenic Origin. Developmental and Comparative ImmunologY, 14 (1). pp. 31-38. |
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| Relation |
http://dx.doi.org/ 10.1016/0145-305X(90)90005-Y
http://www.eprints.iicb.res.in/1222/ |
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