Synthesis and in vitro study of 14-aryl-14H-dibenzo[a.j]xanthenes as cytotoxic agents
IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu
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| Title |
Synthesis and in vitro study of 14-aryl-14H-dibenzo[a.j]xanthenes as cytotoxic agents
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| Creator |
Bhattacharya, Asish K.
Rana, Kalpeshkumar C. Mujahid, Mohammad Sehar, Irum Saxena, Ajit K. |
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| Subject |
Chemical Sciences
Pharmacological Sciences |
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| Description |
A simple and expedient method for the synthesis of a series of 14-aryl-14H-dibenzo[a.j]xanthenes is described through a one-pot condensation of b-naphthol with aryl aldehydes catalysed by TaCl5 under solvent-free conventional heating. The major advantages of the present method are: high yields, less reaction time, solvent-free condition and easy purification of the products. The synthesized 14-aryl-
14H-dibenzo[a.j]xanthenes were evaluated against a panel of six human cancer lines of different tissues.Synthesized compound 3o showed IC50 of 37.9 and 41.3 lM against Colo-205 and 502713, respectively,whereas 3g showed IC50 of 41.9 lM against Colo-205.
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| Date |
2009
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://iiim.csircentral.net/354/1/10.1016j.bmcl.2009.08.033.pdf
Bhattacharya, Asish K. and Rana, Kalpeshkumar C. and Mujahid, Mohammad and Sehar, Irum and Saxena, Ajit K. (2009) Synthesis and in vitro study of 14-aryl-14H-dibenzo[a.j]xanthenes as cytotoxic agents. Bioorganic & Medicinal Chemistry Letters, 19 (19). pp. 5590-5593. ISSN 0960894X |
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| Relation |
http://dx.doi.org/10.1016/j.bmcl.2009.08.033
http://iiim.csircentral.net/354/ |
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