Evaluation of antioxidant and antimicrobial activities of Bergenin and its derivatives obtained by chemoenzymatic synthesis
IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu
View Archive Info| Field | Value | |
| Title |
Evaluation of antioxidant and antimicrobial activities of Bergenin and its derivatives obtained by chemoenzymatic synthesis
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| Creator |
Nazir, Nighat
Koul, Surrinder Qurishi, Mushtaq Ahmad Najar, Muzaffar Hussain Zargar, Mohammed Iqbal |
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| Subject |
Chemical Sciences
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| Description |
Bergenin pentacetate (2), a peracetate derivative of biologically active lead compound Bergenin (1) isolated from Bergenia stracheyi was subjected to lipase catalyzed regioselective alcoholysis to obtain 3,4,10,11-tetracetate of Bergenin (3). The free hydroxyl group of 3 was derivatised using higher carboxylic acids to obtain acyl derivatives (4–7). These compounds synthesized via chemoenzymatic route were characterized using 1H NMR, 13C NMR and mass spectral data and evaluated for DPPH radical scavenging, antimicrobial and xanthine oxidase inhibitory activities. The studies revealed that biological activity of Bergenin can be optimized by selective modification of its structure.
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| Date |
2011
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://iiim.csircentral.net/375/1/10.1016%2Dj%2Dejmech.2011.03.025.PDF
Nazir, Nighat and Koul, Surrinder and Qurishi, Mushtaq Ahmad and Najar, Muzaffar Hussain and Zargar, Mohammed Iqbal (2011) Evaluation of antioxidant and antimicrobial activities of Bergenin and its derivatives obtained by chemoenzymatic synthesis. European Journal of Medicinal Chemistry, 46 (6). pp. 2415-2420. ISSN 02235234 |
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| Relation |
http://dx.doi.org/10.1016/j.ejmech.2011.03.025
http://iiim.csircentral.net/375/ |
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