Synthesis, anti-inflammatory and anticancer activity evaluation of some novel acridine derivatives
IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu
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| Title |
Synthesis, anti-inflammatory and anticancer activity evaluation of some novel acridine derivatives
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| Creator |
Sondhi, Sham M.
Singh, Jaiveer Rani, Reshma Gupta, P.P. Agrawal, S.K. Saxena, A.K. |
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| Subject |
Chemical Sciences
Pharmacological Sciences |
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| Description |
Condensation of 9-chloro-2,4-(un)substituted acridines (1a–c) with various amines (2a–e) and 9-isothiocyanato-
2,4-(un)substituted acridines (4a,b) with different amines (2a,b,d,e) gave condensed products 3a–o and 5a–g respectively. Compounds 3a–o and 5a–g were screened for anti-inflammatory activity at a dose of 50 mg/kg p.o. Compound 3e exhibited 41.17% anti-inflammatory activity which is better than most commonly used standard drug ibuprofen which showed 39% anti-inflammatory (at 50 mg/kg p.o.) activity. Anticancer activity evaluation of compounds 3a–o and 5a–g was carried out against a small panel of human cancer cell lines and compounds 3g, 3m and 5g exhibited good anticancer activity against breast (MCF-7), liver (HEP-2), colon (COLO-205, 502713, HCT-15), lung (A-549)and neuroblastoma (IMR-32) cancer cell lines at a concentration of 1� 10�5 M.
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| Date |
2010
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://iiim.csircentral.net/358/1/10.1016j.ejmech.2009.10.042.pdf
Sondhi, Sham M. and Singh, Jaiveer and Rani, Reshma and Gupta, P.P. and Agrawal, S.K. and Saxena, A.K. (2010) Synthesis, anti-inflammatory and anticancer activity evaluation of some novel acridine derivatives. European Journal of Medicinal Chemistry, 45 (2). pp. 555-563. ISSN 02235234 |
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| Relation |
http://dx.doi.org/10.1016/j.ejmech.2009.10.042
http://iiim.csircentral.net/358/ |
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