Structure–activity relationship (SAR) of parthenin analogues with pro-apoptotic activity: Development of novel anti-cancer leads
IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu
View Archive Info| Field | Value | |
| Title |
Structure–activity relationship (SAR) of parthenin analogues with pro-apoptotic activity: Development of novel anti-cancer leads
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| Creator |
Shah, Bhahwal Ali
Kaur, Rajbir Gupta, Pankaj Kumar, Ajay Sethi, Vijay Kumar Andotra, Samar Singh Singh, Jaswant Saxena, Ajit Kumar Taneja, Subhash Chandra |
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| Subject |
Chemical Sciences
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| Description |
Analogues of parthenin were synthesized by substitutions at different reaction centres to establish a structure–activity relationship (SAR). Some of the molecules have displayed significant cytotoxicity in human cervical carcinoma (HeLa) and human myeloid leukemia (HL-60) cells. A few of the compounds also induced apoptosis in HL-60 cells measured in terms of sub-Go/G1 DNA fraction. Also one of the lead
molecules has been shown to be the inhibitor of both telomerase and topoisomerase-II.
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| Date |
2009
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://iiim.csircentral.net/345/1/10.1016j.bmcl.2009.05.089.pdf
Shah, Bhahwal Ali and Kaur, Rajbir and Gupta, Pankaj and Kumar, Ajay and Sethi, Vijay Kumar and Andotra, Samar Singh and Singh, Jaswant and Saxena, Ajit Kumar and Taneja, Subhash Chandra (2009) Structure–activity relationship (SAR) of parthenin analogues with pro-apoptotic activity: Development of novel anti-cancer leads. Bioorganic & Medicinal Chemistry Letters, 19 (15). pp. 4394-4398. ISSN 0960894X |
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| Relation |
http://dx.doi.org/10.1016/j.bmcl.2009.05.089
http://iiim.csircentral.net/345/ |
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