A Quantitative Structure Activity Relationship Study on Permeation of Amino Acids in Enantioselective Membranes
IR@NEIST: CSIR-North East Institute of Science and Technology, Jorhat
View Archive Info| Field | Value | |
| Title |
A Quantitative Structure Activity Relationship Study on Permeation of Amino Acids in Enantioselective Membranes
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| Creator |
HAZARIKA , S
DUTTA , N N RAO, P G |
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| Subject |
Chemical Engineering
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| Description |
The permeation of seven isomers of amino acids (AA) namely Tryptophan (Trp), Phenylalanine (Phe), Tyrosine
(Tyr), Phenylglycine (Phegly), Methionine (Meth), Threonine (Thr)and Serine (Ser) was studied using an
enantioselective membrane prepared from polysulphone containing L-tryptophan-glutaraldehyde condensation
product in the polymer matrix. The experiments were conducted in dialysis mode under optimized condition of the
aqueous phase pH and salt concentration in a two compartment membrane cell. The membrane was found to
exhibit selectivity towards all the D-isomers of amino acids studied in this work. In order to deduce implication on
the design of suitable membrane system for specific application, a quantitative structure activity relationship analysis
has been made using hydrophobicity as the molecular descriptor. In this analysis, the solute fluxes were analysed
on the basis of a permeation model consisting of diffusing flow alone. Finally, the model parameters of the diffusive
flux of both isomers were correlated with hydrophobicity taken as the molecular property
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| Date |
2006-06-02
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://neist.csircentral.net/288/1/2599_J_Appl_Memb_sci_2006_2p.13%2D29.pdf
HAZARIKA , S and DUTTA , N N and RAO, P G (2006) A Quantitative Structure Activity Relationship Study on Permeation of Amino Acids in Enantioselective Membranes. J Applied Membrane Science & Technology. pp. 13-29. |
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| Relation |
http://neist.csircentral.net/288/
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