Antimutagenic potential of chickrassy(Chukrasia tabularis A.Juss)bark
IR@IHBT: CSIR-Institute of Himalayan Bioresource Technology, Palampur
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| Title |
Antimutagenic potential of chickrassy(Chukrasia tabularis A.Juss)bark
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| Creator |
Kaur, R
Sharma, U Singh , Bikram Arora, S |
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| Subject |
Natural Product Chemistry
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| Description |
The present study aims to assess the antimutagenic potential of methanol extract and different fractions(hexane,ethyl acetate and butanol) of chickrassy (Chukrasia tabularis), belonging to family meliaceae by employing histidine point reversion assay. The antimutagenic effect was evaluated aganist mutagens,4-Nitro-o-phenylenedianine and sodium azide and promutagenic,2-Aminofluorene of TA98 and TA100 strain of Salmonella typhimurium. The co-incubation and pre-incubation mode of treatments were used to evaluate the bioantimutagenic and desmutagenic effects, respectively.From the results obtained, it was clear that methanol extract and its fractions showed more desmutagenic effect than bionatimutagenic effect.The methanol extract was found to be most active in TA998 while ethyl acetate fraction showed good results in TA100 strain against both promutagen and direct acting mutagen.HPLC analysis of methanol extract was carried out for the identification chemical constituents and the results revealed that catechin,quercetin and rutin have contributed to its antimutagenic activity.
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| Date |
2011
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://ihbt.csircentral.net/898/1/Antimutagenic__potential_of_chickrassy.pdf
Kaur, R and Sharma, U and Singh , Bikram and Arora, S (2011) Antimutagenic potential of chickrassy(Chukrasia tabularis A.Juss)bark. Journal of Medicinal Plants Research, 5. |
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| Relation |
http://ihbt.csircentral.net/898/
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