Nanoencapsulation and characterization of Albizia chinensis isolated antioxidant quercitrin on PLA nanoparticles
IR@IHBT: CSIR-Institute of Himalayan Bioresource Technology, Palampur
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Title |
Nanoencapsulation and characterization of Albizia chinensis isolated antioxidant
quercitrin on PLA nanoparticles
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Creator |
Kumari, A
Yadav , S K Pakade, Yogesh B Kumar, Vineet Singh , Bikram Chaudhary, A Yadav, S C |
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Subject |
Plant sciences
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Description |
The plant isolated antioxidant quercitrin has been encapsulated on poly-d,l-lactide (PLA) nanoparticles
by solvent evaporation method to improve the solubility, permeability and stability of this molecule.
The size of quercitrin-PLA nanoparticles is 250±68nm whereas that PLA nanoparticles is 195±55 nm.
The encapsulation efficiency of nanoencapsulated quercitrin evaluated by HPLC and antioxidant assay is
40%. The in vitro release kinetics of quercitrin under physiological condition reveals initial burst release
followed by sustained release. Less fluorescence quenching is observed with equimolar concentration of
PLA encapsulated quercitrin than free quercitrin. The presence of quercitrin specific peaks on FTIR of five
times washed quercitrin loaded PLA nanoparticles provides an extra evidence for the encapsulation of
quercitrin into PLA nanoparticles. These properties of quercitrin nanomedicine provide a new potential
for the use of such less useful highly active antioxidant molecule towards the development of better
therapeutic for intestinal anti-inflammatory effect and nutraceutical compounds.
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Date |
2011
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Type |
Article
PeerReviewed |
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Format |
application/pdf
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Identifier |
http://ihbt.csircentral.net/920/1/quercitrin_paper.pdf
Kumari, A and Yadav , S K and Pakade, Yogesh B and Kumar, Vineet and Singh , Bikram and Chaudhary, A and Yadav, S C (2011) Nanoencapsulation and characterization of Albizia chinensis isolated antioxidant quercitrin on PLA nanoparticles. Colloids and Surfaces B: Biointerfaces , 82. pp. 224-232. |
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Relation |
http://ihbt.csircentral.net/920/
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