Hydrotrope-driven disruption of micellar encapsulants for voltammetric detection of triclosan
IR@CECRI: CSIR-Central Electrochemical Research Institute, Karaikudi
View Archive Info| Field | Value | |
| Title |
Hydrotrope-driven disruption of micellar encapsulants for
voltammetric detection of triclosan
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| Creator |
Raghupathy, P.
Mathiyarasu, J. Joseph, J. Phani, K.L.N. Yegnaraman, V. |
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| Subject |
Electrodics and Electrocatalysis
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| Description |
The effect of surfactant matrices on the voltammetry of an antimicrobial agent, triclosan (TCN) and its release into the aqueous
continuous phase for voltammetric detection have been studied in this paper. As the surfactant concentration (wt%) was increased,
the peak current was found to decrease in the order: Tween-80 > Tween-60 >>> sodium laurylsulphate. The results of these experiments
are found to correlate with the published data obtained using microcalorimetry. Attempts have been made to overcome the
trapping effect of surfactant matrices by designing a solution composition based on hydrotrope-driven disruption of micellar encapsulants
for complete release of TCN into the analyte solution for voltammetric detection. The hydrotropes employed in this study are
sodium p-toluenesulphonate and sodium benzenesulphonate. The experiments intended to show the effect of hydrotropes on the
�pre-adsorbed� triclosan-surfactant ‘‘pseudo-complex’’ proved that hydrotrope-driven disruption of micelles takes place even on
the electrode surface. Thus, immersion of the surfactant-covered electrode into a hydrotrope solution can ‘‘strip’’ the antimicrobial
agent off the surfactant. The results of these proof-of-concept experiments were applied to the analysis of low concentrations (0.1–
0.8 mM) in product formulations containing TCN. A linear relationship was found between TCN concentration and current magnitude
with a correlation coefficient of 0.97, the sensitivity of the measurement towards the TCN oxidation being 12.8 lAmM�1.
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| Publisher |
Elsevier
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| Date |
2005
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://cecri.csircentral.net/100/1/050-2005.pdf
Raghupathy, P. and Mathiyarasu, J. and Joseph, J. and Phani, K.L.N. and Yegnaraman, V. (2005) Hydrotrope-driven disruption of micellar encapsulants for voltammetric detection of triclosan. Journal of Electroanalytical Chemistry, 584 (2). pp. 210-214. |
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| Relation |
http://cecri.csircentral.net/100/
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