Role of Intrinsic Disorder in Transient Interactions of Hub Proteins
IR@IGIB: CSIR-Institute of Genomics & Integrative Biology, New Delhi
View Archive Info| Field | Value | |
| Title |
Role of Intrinsic Disorder in Transient Interactions
of Hub Proteins
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| Creator |
Singh , Gajinder Pal
Ganapathi, Mythily Dash, Debasis |
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| Subject |
BI1 Bioinformatics (General)
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| Description |
Hubs in the protein-protein interaction network have been classified as "party" hubs, which are highly correlated in their mRNA expression with their partners while "date" hubs show lesser correlation. In this study, we explored the role of intrinsic disorder in date and party hub interactions. The data reveals that intrinsic disorder is significantly enriched in date hub proteins when compared with party hub proteins. Intrinsic disorder has been largely implicated in transient binding interactions. The disorder to order transition, which occurs during binding interactions in disordered regions, renders the interaction highly reversible while maintaining the high specificity. The enrichment of intrinsic disorder in date hubs may facilitate transient interactions, which might be required for date hubs to interact with different partners at different times.
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| Date |
2006-12-11
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://openaccess.igib.res.in/117/1/hubsdisordered.pdf
Singh , Gajinder Pal and Ganapathi, Mythily and Dash, Debasis (2006) Role of Intrinsic Disorder in Transient Interactions of Hub Proteins. Role of Intrinsic Disorder in Transient Interactions of Hub Proteins, 66 (4). pp. 761-765. |
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| Relation |
http://openaccess.igib.res.in/117/
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