A sufficiency analysis of asymptotic stability in continuous recombinant fermentation with auxotrophic mutants
IR@IMTECH: CSIR-Institute of Microbial Technology, Chandigarh
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| Title |
A sufficiency analysis of asymptotic stability in continuous recombinant fermentation with auxotrophic mutants
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| Creator |
Patnaik, P R
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| Subject |
QD Chemistry
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| Description |
Fermentations employing genetically modified microorganisms are sensitive to the disturbances likely in large bioreactors. Since these disturbances may affect the competition between recombinant cells and plasmid-free cells, with consequent effects on plasmid stability and reactor stability, it is useful to identify regions of asymptoticstability (RAS) which do not vary with shifts in the operating condition. Using a model for continuousfermentation with auxotrophicmutants, sufficient conditions have been derived for such operationally invariant RAS. Plots for Saccharomyces cerevisiae containing the pBR322 plasmid show that improving the segregational stability makes the fermentation more vulnerable to disturbances. Thus, real reactor operation must balance both kinds of stability.
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| Publisher |
Elsevier Science
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| Date |
1998
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://crdd.osdd.net/open/790/1/patnaik1998.2.pdf
Patnaik, P R (1998) A sufficiency analysis of asymptotic stability in continuous recombinant fermentation with auxotrophic mutants. Biochemical Engineering Journal, 2 (2). pp. 157-160. ISSN 1369703X |
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| Relation |
http://dx.doi.org/10.1016/S1369-703X(98)00028-X
http://crdd.osdd.net/open/790/ |
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