Apoptosis of Th1-like cells in experimental tuberculosis (TB)
IR@IMTECH: CSIR-Institute of Microbial Technology, Chandigarh
View Archive Info| Field | Value | |
| Title |
Apoptosis of Th1-like cells in experimental tuberculosis (TB)
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| Creator |
Das, G
Vohra, H Saha, B Agrewala, J N Mishra, G C |
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| Subject |
QR180 Immunology
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| Description |
Th1 cell-induced anti-mycobacterial immunity is lost during a progressive Mycobacterium tuberculosis infection in a susceptible host. This study was designed to test the mechanism of the loss of anti-mycobacterial cell-mediated immune response. We demonstrate that M. tuberculosis infection results in increased Fas expression and decreased Bcl-2 expression in CD4+ T cells. When CD4+ T cells are stimulated in vitro, they show increased apoptosis and decreased production of IL-2 and interferon-gamma (IFN-γ) but not of IL-4. These changes may result in selective apoptosis of Th1-like cells, leading to the loss of cell-mediated immune response against M. tuberculosis.
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| Publisher |
Wiley
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| Date |
1999
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://crdd.osdd.net/open/797/1/agrewala1999.1.pdf
Das, G and Vohra, H and Saha, B and Agrewala, J N and Mishra, G C (1999) Apoptosis of Th1-like cells in experimental tuberculosis (TB). Clinical and Experimental Immunology, 115 (2). pp. 324-328. ISSN 0009-9104 |
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| Relation |
http://dx.doi.org/10.1046/j.1365-2249.1999.00755.x
http://crdd.osdd.net/open/797/ |
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