Pd-Catalyzed Orthogonal Knoevenagel/Perkin Condensation– Decarboxylation–Heck/Suzuki Sequences: Tandem Transformations of Benzaldehydes into Hydroxy-Functionalized Antidiabetic Stilbene– Cinnamoyl Hybrids and Asymmetric Distyrylbenzenes
IR@IHBT: CSIR-Institute of Himalayan Bioresource Technology, Palampur
View Archive Info| Field | Value | |
| Title |
Pd-Catalyzed Orthogonal Knoevenagel/Perkin Condensation–
Decarboxylation–Heck/Suzuki Sequences: Tandem Transformations of
Benzaldehydes into Hydroxy-Functionalized Antidiabetic Stilbene–
Cinnamoyl Hybrids and Asymmetric Distyrylbenzenes
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| Creator |
Sharma, N
Sharma , A Shard, A Kumar, R ---, Saima Sinha, Arun K |
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| Subject |
Plant sciences
Natural Product Chemistry |
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| Description |
Abstract: Tandem reactions that involve chemoselective Knoevenagel/Perkin condensation–
decarboxylation–Heck/Suzuki coupling or Heck–aldol sequences have
been achieved. This enabled the first concise and efficient synthesis of several important
hydroxy-functionalized compound classes, such as stilbene–cinnamoyl hybrids
(potent protein tyrosine phosphatase1B inhibitors), cinnamoyl–cinnamic acid
hybrids, asymmetric distyrylbenzenes, and biarylstyrenes. Previously reported synthesis
require multiple steps and protection/deprotection manipulations
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| Date |
2011
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://ihbt.csircentral.net/941/1/31%2D01%2D2012_Catalyzed.pdf
Sharma, N and Sharma , A and Shard, A and Kumar, R and ---, Saima and Sinha, Arun K (2011) Pd-Catalyzed Orthogonal Knoevenagel/Perkin Condensation– Decarboxylation–Heck/Suzuki Sequences: Tandem Transformations of Benzaldehydes into Hydroxy-Functionalized Antidiabetic Stilbene– Cinnamoyl Hybrids and Asymmetric Distyrylbenzenes. Chemistry A European Journal, 17 (10). pp. 350-356. |
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| Relation |
http://ihbt.csircentral.net/941/
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