Amine and thiazole substituted !-butyrolactones from naturally occurring limonene
IR@IHBT: CSIR-Institute of Himalayan Bioresource Technology, Palampur
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| Title |
Amine and thiazole substituted !-butyrolactones
from naturally occurring limonene
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| Creator |
Kaur, P
Das, Pralay Chaudhary, A Singh , Bikram |
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| Subject |
Plant sciences
Natural Product Chemistry |
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| Description |
Abstract: Substituted g-butyrolactones are important structural motifs in several natural products and pharmaceuticals. In
this paper, we report the synthesis of novel g-butyrolactone amine and thiazole derivatives from naturally occurring limonene.
Regioselective bromination followed by nucleophilic substitution with different amines and thiourea gave desired products
in moderate yield.
Key words: regioselectivity, bromination, amination, thiazole, g-butyrolactone.
Résumé : Les g-butyrolactones substituées sont d’importants motifs structuraux dans plusieurs produits naturels et pharmaceutiques.
Dans ce travail, on a synthétisé de nouveaux dérivés amine et thiazole de la g-butyrolactone à partir du limonène
qu’on peut obtenir de sources naturelles. La bromation régiosélective, suivie d’une substitution nucléophile avec diverses
amines et thiourées permet d’obtenir les produits désirés avec des rendements modérés
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| Date |
2011
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://ihbt.csircentral.net/961/1/Amine_and_thiazole_substituted_!%2Dbutyrolactones.pdf
Kaur, P and Das, Pralay and Chaudhary, A and Singh , Bikram (2011) Amine and thiazole substituted !-butyrolactones from naturally occurring limonene. Journal of Chemistry, 89. pp. 639-644. |
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| Relation |
http://ihbt.csircentral.net/961/
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