Evaluation of Antileishmanial Activity of trans-Aconitic Acid
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Evaluation of Antileishmanial Activity of trans-Aconitic Acid
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| Creator |
Misra, Sujata
Sanyal, Tapati Sarkar, Dwijen Bhattacharya, Prabhat K Ghosh, Dilip K |
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| Subject |
Infectious Diseases and Immunology
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| Description |
Leishmania donovani is a digenetic hemoflagellate alternating between the flagellated promastigote in the vector and the rudimentary flagellated amastigote
form in the macrophages causing visceral leishmaniasis or kala-azar. Leishman-iasis is treated with antileishmanial drugs or the diamidine group of compounds but the toxicity of these compounds limits their use. In this context, the obser-vation of Pfaller and Mat-r (1) regarding selective toxicity of allopurinol for the parasite due to variations in its purine and pyrimidine metabolism is noteworthy
(2,3). The drug is relatively nontoxic and is used along with the antileishmanial drugs in the chemotherapy of visceral leishmaniasis.The present study was undertaken with the antimetabolite trans-aconitic acid(TAA) which inhibits the enzyme aconitase. The enzymes of the TCA cycle have been demonstrated in different species of leishmania (4). The portion of the TCA cycle from isocitrate to a-ketoglutarate and oxaloacetate to fumarate is very
active in leishmania as revealed from the specific activities of the different en-zymes of the TCA cycle (5). The enzyme aconitase which catalyzes two initial steps of the TCA cycle has been demonstrated in both the forms of L. donovani
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| Date |
1989
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1390/1/BIOCHEMICAL_MEDICINE_AND_METABOLIC_BIOLOGY__Volume_42___Issue_3___Pages_171%2D178_%2C1989[3].pdf
Misra, Sujata and Sanyal, Tapati and Sarkar, Dwijen and Bhattacharya, Prabhat K and Ghosh, Dilip K (1989) Evaluation of Antileishmanial Activity of trans-Aconitic Acid. BIOCHEMICAL MEDICINE AND METABOLIC BIOLOGY, 42 (3). pp. 171-178. |
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| Relation |
http://dx.doi.org/10.1016/0885-4505(89)90052-2
http://www.eprints.iicb.res.in/1390/ |
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