Furazolidone-Induced Interstrand Cross-Links in Vibrio cholerae DNA. Study of Conformational Change by Circular Dichroism
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Furazolidone-Induced Interstrand Cross-Links in Vibrio cholerae DNA. Study of Conformational Change by Circular Dichroism
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| Creator |
Chatterjee, S N
Basak, Jayasri Maiti, M |
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| Subject |
Chemistry
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| Description |
Vibrio cholerae DN A bearing furazolidone-induced interstrand cross-links show a change in the characteristic
circular dichroism spectra of the DN A itself in dilute buffer. The change in c.d. spectra was characterized by a
shift of the positive band around 272 nm to lower wavelength and a loss of ellipticity of the negative band around 242 nm, and is similar to that exhibited by mitomycin linked Vibrio cholerae DN A under identical conditions and is suggestive of a conformational change of DNA bearing such cross-links. Both furazolidone-induced and
mitomycin-induced cross-linking of Vibrio cholerae DN A inhibited the salt-induced conformation change, i.e.
increase in winding angle of DNA, the percentage inhibition being greater for mitomycin-linked DNA.
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| Publisher |
Elsevier
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| Date |
1989
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1394/1/INTERNATIONAL_JOURNAL_OF_BIOLOGICAL_MACROMOLECULES__Volume_11___Issue_3___Pages_172%2D176_%2C1989[30].pdf
Chatterjee, S N and Basak, Jayasri and Maiti, M (1989) Furazolidone-Induced Interstrand Cross-Links in Vibrio cholerae DNA. Study of Conformational Change by Circular Dichroism. International Journal of Biological Macromolecules, 11 (3). pp. 172-176. |
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| Relation |
http://dx.doi.org/10.1016/0141-8130(89)90064-0
http://www.eprints.iicb.res.in/1394/ |
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