Thyroid Hormone induces Myocardial Matrix Degradation by Activating Matrix Metalloproteinase-1
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Thyroid Hormone induces Myocardial Matrix Degradation by Activating Matrix Metalloproteinase-1
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| Creator |
Ghose Roy, Sreerupa
Mishra, Sumita Ghosh, Goutam Bandyopadhyay, Arun |
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| Subject |
Cell Biology & Physiology
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| Description |
Hyperthyroid patients develop left ventricular hypertrophy associated with alterations of several cardiac parameters such as heart rate, cardiac
output, cardiac contraction and hemodynamic overload leading to cardiac complications. Although cardiac hypertrophy and contractile
abnormality occur, interstitial fibrosis in the heart usually does not take place in hyperthyroid condition. Therefore, in the present study, the
mechanism regulating myocardial extracellular matrix (ECM) remodeling in hyperthyroid condition was investigated. Cardiac hypertrophy was
developed in Sprague–Dawley rats by administration of 3,5,3′-triiodo-L-thyronine (triiodothyronine, 8 μg/100g BW, ip, SID) and
glucocorticosteroid, dexamethasone (DEX, 35 μg/100g BW, po, SID), which is also an inducer of hypertrophy for 15 days. Heart/Body
weight ratio and atrial and brain natriuretic peptide mRNAs were significantly increased in both triiodothyronine- and DEX-treated rats compared
to control. Collagens-I and -III deposition in the left ventricular sections was reduced in triiodothyronine-treated rats, whereas in DEX-treated
animals those were increased compared to control. While mRNA and protein levels of procollagens-I and -III were increased with triiodothyronine
(pb0.01), the levels of mature collagens-I and -III were decreased. The levels of the mature collagens were increased with DEX compared to
control. MMP-1 activity in the serum and left ventricle was higher with reduced levels of TIMPs-3 and -4 in the left ventricle of triiodothyroninetreated
rats. The results suggest that accelerated breakdown of collagens-I and -III by MMP-1 due to suppression of the endogenous TIMPs plays
an important role in regulating the ECM in myocardium of hyperthyroid rat.
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| Publisher |
Elsevier
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| Date |
2007
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1411/1/MATRIX_BIOLOGY___26__(4_)269%2D279_;2007[93].pdf
Ghose Roy, Sreerupa and Mishra, Sumita and Ghosh, Goutam and Bandyopadhyay, Arun (2007) Thyroid Hormone induces Myocardial Matrix Degradation by Activating Matrix Metalloproteinase-1. Matrix Biology, 26 (4). pp. 269-279. |
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| Relation |
http://dx.doi.org/10.1016/j.matbio.2006.12.005
http://www.eprints.iicb.res.in/1411/ |
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