Possible Functional Role of Subtance P on the Mammalian Motor Nerve Terminals
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Possible Functional Role of Subtance P on the Mammalian Motor Nerve Terminals
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| Creator |
Ganquly, D K
Das, M Das Gupta, A K Chauhan, S P S |
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| Subject |
Drug Development/Diagnostics & Biotechnology
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| Description |
The effect of substance P (sP) on mammalian
skeletal myoneural transmission was studied employing
innervated and denervated isolated rat diaphragm
preparations, sP at a concentration of 3.7 nM facilitated
the indirect twitch responses of the rat diaphragm
and antagonised the paralytic effect of d-tubocurarine
(d-Tc). sP failed to affect the direct twitch responses
as well as the contractures induced by acetylcholine
(ACh) and potassium chloride (KCI) in the
denervated diaphragm. The amount of ACh released into
the bathing medium in response to tetanic stimulation
of the phrenic nerve was doubled in presence of sP.
The study illustrates a presynaptic facilitatory
involvement of sP on mammalian myoneural transmission.
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| Publisher |
Elsevier
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| Date |
1987
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1436/1/LIFE_SCIENCES__40_(3)_289%2D292;1987[62].pdf
Ganquly, D K and Das, M and Das Gupta, A K and Chauhan, S P S (1987) Possible Functional Role of Subtance P on the Mammalian Motor Nerve Terminals. Life Sciences, 40 (3). pp. 289-292. |
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| Relation |
http://dx.doi.org/10.1016/0024-3205(87)90345-6
http://www.eprints.iicb.res.in/1436/ |
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