Role of Mannose/N-Acetylglucosamine Receptors in Blood Clearance and Cellular Attachment of Leishmania Donovani
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Role of Mannose/N-Acetylglucosamine Receptors in Blood Clearance and Cellular Attachment of Leishmania Donovani
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| Creator |
Chakraborty, Prasanta
Das, Pijush K |
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| Subject |
Infectious Diseases and Immunology
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| Description |
The effects of glycoprotei~ and neoglycoproteins specific for liver and macrophage membrane lectins on both the cellular attachment
and the clearance of Leishmania donovani from hamster blood were investigated. Although the inhibition pattern of in
vitro cellular attachment studies indicates the involvement of both galactose and mannose/N-acetylglucosamine receptors, the in
vivo blood clearance of the parasites was inhibited only by glycoproteins and neoglycoproteins specific for m.r.nnose/N-acetylglucosamine
receptors. The inhibitory effects on blood clearance were abolished by pretreating the parasites with tunicamycin, an
inhibitor of protein glycosylation. These results indicate that the mannose/N-acetylghicosandne hepatic lectin recognizes specific
sugars on the parasite Surface and is important to the promastigote during the early stages of infection.
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| Publisher |
Elsevier
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| Date |
1988
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1456/1/MOLECULAR_AND_BIOCHEMICAL_PARASITOLOGY__Volume_28___Issue_1___Pages_55%2D62;1988[59].pdf
Chakraborty, Prasanta and Das, Pijush K (1988) Role of Mannose/N-Acetylglucosamine Receptors in Blood Clearance and Cellular Attachment of Leishmania Donovani. Molecular and Biochemical Parasitology, 28 (1). pp. 55-62. |
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| Relation |
http://dx.doi.org/10.1016/0166-6851(88)90180-6
http://www.eprints.iicb.res.in/1456/ |
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