A Study on Cybrid Model of Parkinson’s Disease
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
A Study on Cybrid Model of Parkinson’s Disease
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| Creator |
Appukuttan, T A
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| Subject |
Cell Biology & Physiology
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| Description |
Parkinson’s disease (PD) is a neurodegenerative disease characterized by specific loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) region of the
brain. Of the many known causes or risk factors till date mitochondrial dysfunction is considered to play one of the major roles in the pathogenesis of the disease. Existence
of mitochondrial dysfunction is reported in the blood and brain of parkinsonian patients. Reports suggest complex I inhibition in the postmortem brain samples of idiopathic PD patients. Though there are various cell and animal models to approach and study the mitochondrial genetics and proteomics the correct representation of the mitochondrial dysfunction occurring in humans cannot be mirrored in such condition. Human cell line study is one way to represent the disease pathology occurring and for investigating the causes and also for designing novel drugs for the treatment of the disease.
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| Date |
2012
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| Type |
Thesis
NonPeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1466/1/THESIS.pdf
Appukuttan, T A (2012) A Study on Cybrid Model of Parkinson’s Disease. PhD thesis, Jadavpur University. |
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| Relation |
http://www.eprints.iicb.res.in/1466/
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