Tryptamine-Gallic Acid Hybrid Prevents Non-steroidal Anti-inflammatory Drug-induced Gastropathy
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Tryptamine-Gallic Acid Hybrid Prevents Non-steroidal
Anti-inflammatory Drug-induced Gastropathy
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| Creator |
Pal, Chinmay
Bindu, Samik Dey, Sumanta Alam, Athar Goyal, Manish Iqbal, Mohd. Shameel Sarkar, Souvik Kumar, Rahul Halder, Kamal Krishna Chatterjee Debnath, Mita Adhikari, Susanta Bandyopadhyay, Uday |
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| Subject |
Infectious Diseases and Immunology
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| Description |
Non-steroidal anti-inflammatory drugs (NSAIDs) induce gastropathy by promoting mitochondrial pathology,
oxidative stress, and apoptosis in gastric mucosal cells.
We have synthesized SEGA (3a), a tryptamine-gallic acid hybrid, which prevents NSAID-induced gastropathy by
preventing mitochondrial oxidative stress, dysfunction, and apoptosis.
SEGA (3a) bears an immense therapeutic potential against NSAID-induced gastropathy.
This novel molecule is a significant addition in the discovery of gastroprotective drugs.
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| Publisher |
American Society for Biochemistry and Molecular Biology
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| Date |
2012
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1533/1/OURNAL_OF_BIOLOGICAL_CHEMISTRY_287(_5)3495%2D3509;2912[63].pdf
Pal, Chinmay and Bindu, Samik and Dey, Sumanta and Alam, Athar and Goyal, Manish and Iqbal, Mohd. Shameel and Sarkar, Souvik and Kumar, Rahul and Halder, Kamal Krishna and Chatterjee Debnath, Mita and Adhikari, Susanta and Bandyopadhyay, Uday (2012) Tryptamine-Gallic Acid Hybrid Prevents Non-steroidal Anti-inflammatory Drug-induced Gastropathy. The Journal of Biological Chemistry, 287 (5). pp. 3495-3509. |
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| Relation |
http://dx.doi.org/10.1074/jbc.M111.307199
http://www.eprints.iicb.res.in/1533/ |
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