Synthesis, antibacterial and antimutagenic activity of zerumbonebicarbonyl analogues
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
View Archive Info| Field | Value | |
| Relation |
http://ir.cftri.com/12599/
http://dx.doi.org/10.1016/j.foodchem.2016.11.136 |
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| Title |
Synthesis, antibacterial and antimutagenic activity of zerumbonebicarbonyl
analogues
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| Creator |
Santosh Kumar, S. C.
Negi, P. S. Manjunatha, J. R. Bettadaiah, B. K. |
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| Subject |
30 Spices/Condiments
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| Description |
Synthesis of new zerumbone-bicarbonyl analogues by SeO2 oxidation is reported. Selective oxidation of
methyl at C-13 to an aldehyde and a ketone with exo-cyclic double bond between C-13 and C-6 in zerumbone
has been recognized. Both these compounds have an additional conjugated-carbonyl-functionality.
They exhibited significantly higher antimutagenic activity than zerumbone against Salmonella tester
strains. They are more active against Gram positive bacteria than Gram negative bacteria; however
zerumbone showed highest activity against E. coli, whereas its derivatives were least effective against
E. coli.
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| Date |
2017
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Language |
en
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| Rights |
—
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| Identifier |
http://ir.cftri.com/12599/1/Food%20Chemistry%20221%20%282017%29%20576%E2%80%93581.pdf
Santosh Kumar, S. C. and Negi, P. S. and Manjunatha, J. R. and Bettadaiah, B. K. (2017) Synthesis, antibacterial and antimutagenic activity of zerumbonebicarbonyl analogues. Food Chemistry, 221. pp. 576-581. |
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