Galectin-3 in urine of cancer patients: stage and tissue specificity
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
View Archive Info| Field | Value | |
| Relation |
http://ir.cftri.com/10080/
JCR-01-09 |
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| Title |
Galectin-3 in urine of cancer patients: stage and tissue specificity
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| Creator |
Kiruthika, Balasubramanian
Raghavendra, Vasudevamurthy Sathisha, U. V. Anil, Thomas |
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| Subject |
29 Protein Chemistry
01 Medical sciences |
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| Description |
Purpose Galectin-3 has been implicated in advanced
stage of cancer disease. In the current study we examined
the possibility of urinary galectin-3 levels to stage cancer
disease and to follow up therapy.
Experimental design Urine was collected from all types of
cancer patients at diVerent stages including patients undergoing
radio/chemotherapy. Galectin-3 level was determined
by anti-galectin-3 based ELISA and agglutination assays.
Immunoblotting and puriWcation on lactosyl aYnity column
further conWrmed the presence of galectin-3.
Results Cancer samples exhibited stage dependent
expression of galectin-3 approx. ranging from 1.0 to 3.3,
4.4 to 5.4, 5.4 to 24.7, 13.1 to 31.9, 13.9 to 32.9 ng/mg C
(creatinine) for stage I–V, respectively, at P » <0.05 level.
Galectin-3 levels were decreased by approx. threefolds
after 5th day of therapy.
Conclusions Sample collection being simple and noninvasive,
urinary galectin-3 may be used as a potential
diagnostic tool for monitoring or follow up of the stage of
cancer disease.
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| Date |
2009
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/10080/1/Journal_of_Cancer_Research_and_Clinical_Oncology_2009_135_355-.pdf
Kiruthika, Balasubramanian and Raghavendra, Vasudevamurthy and Sathisha, U. V. and Anil, Thomas (2009) Galectin-3 in urine of cancer patients: stage and tissue specificity. Journal of Cancer Research and Clinical Oncology, 135. pp. 355-363. |
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