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Chitosan-glycolipid nanocarriers improve the bioavailability of fucoxanthin via up-regulation of PPARc and SRB1 and antioxidant activity in rat model.

IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore


Field	Value

Relation	http://ir.cftri.com/12741/ http://dx.doi.org/10.1016/j.jff.2016.10.023

Title	Chitosan-glycolipid nanocarriers improve the bioavailability of fucoxanthin via up-regulation of PPARc and SRB1 and antioxidant activity in rat model.

Creator	Ravi, Hindupur. Baskaran, V.

Subject	14 Carotenoid Chemistry

Description	In this study, we have hypothesized that fucoxanthin (FUCO) absorption from nanogels (NGs) may increase. CS-NGs were prepared by using chitosan (CS) with/without GL and studied (i) the FUCO bioavailability upon a single (48 h), repeated (14 d) and dietary (one month) feeding, (ii) the agonistic property of FUCO and GL on PPARc and SRB1 expressions to examine active absorption of FUCO. In single (pmol/mL/48 h) and repeated dose (nmol/mL) study, plasma FUCO was higher by 38.8, 227.5% and 73.3, 292.4% in CS-NGs + GL compared to CS-NGs (�GL) and control groups. In dietary study, plasma FUCO (nmol/mL) was higher by 57.5, 400 and 287% in CS-NGs + GL compared to CS-NGs (�GL), seaweed and control groups. Increased PPARc expression was evident in CS-NGs + GL group depicting GL and FUCO acts an agonist. This is the first report demonstrating advantage of CS-NGs + GL for improved FUCO bioavailability via passive and active transport through PPARc mediated SRB1 activation.

Publisher	Elsevier

Date	2017

Type	Article PeerReviewed

Format	pdf

Language	en

Identifier	http://ir.cftri.com/12741/1/Journal%20of%20Functional%20Foods%2028%20%282017%29%20215%E2%80%93226.pdf Ravi, Hindupur. and Baskaran, V. (2017) Chitosan-glycolipid nanocarriers improve the bioavailability of fucoxanthin via up-regulation of PPARc and SRB1 and antioxidant activity in rat model. Journal of Functional Foods, 28. pp. 215-226. ISSN 1756-4646