Polymer-lipid nanocarriers to improve stability, bioavailability and anti-cancer property of carotenoid fucoxanthin.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
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| Relation |
http://ir.cftri.com/12815/
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| Title |
Polymer-lipid
nanocarriers to improve stability, bioavailability and anti-cancer
property of carotenoid fucoxanthin.
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| Creator |
Ravi, H.
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| Subject |
14 Carotenoid Chemistry
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| Description |
Fucoxanthin (FUCO), a xanthophyll carotenoid is photo-, and thermo-labile and
poorly bioavailable due to its lipophilicity. Stability and bioavailability of FUCO can be
improved by its encapsulation with a suitable polymer matrix and specific lipid. Hence,
nanoencapsulated FUCO was prepared using chitosan (CS) - sodium tripolyphosphate
(TPP) - glycolipid (GL) multifaceted system (CS-NGs) by means of ionic gelation
method. It was hypothesized that nanoencapsulated FUCO in CS-NGs+GL matrix may
favour its intestinal uptake and intracellular trafficking with no toxicity. It was aimed that
GL and FUCO may be an agonist to PPARĪ³ and SRB1 which may result in active
intestinal uptake of FUCO besides passive uptake.
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| Date |
2016
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| Type |
Thesis
NonPeerReviewed |
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| Format |
pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/12815/1/Ravi.pdf
Ravi, H. (2016) Polymer-lipid nanocarriers to improve stability, bioavailability and anti-cancer property of carotenoid fucoxanthin. Doctoral thesis, Central Food Technological Research Institute. |
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