Chitosan-glycolipid nanogels loaded with anti-obese marine carotenoid fucoxanthin: Acute and sub-acute toxicity evaluation in rodent model.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
View Archive Info| Field | Value | |
| Relation |
http://ir.cftri.com/12816/
http://dx.doi.org/10.1177/0885328215590753 |
|
| Title |
Chitosan-glycolipid nanogels loaded
with anti-obese marine carotenoid
fucoxanthin: Acute and sub-acute
toxicity evaluation in rodent model.
|
|
| Creator |
Ravi, Hindupur.
Arunkumar, R. Baskaran, V. |
|
| Subject |
14 Carotenoid Chemistry
17 Toxicology |
|
| Description |
Fucoxanthin (FUCO) is a light- and heat-sensitive marine xanthophyll carotenoid, present in brown algae that render
physiological properties as anti-oxidants. In this study, nanoencapsulation is an approach adopted to improve bioavailability
of FUCO by using ionic-gelation method with polymeric chitosan (CS) dispersed in glycolipid (GL), as a carrier.
Further, the aim was to investigate adverse effect of acute and sub-acute toxicity of chitosan nanogels (CS-NGs) loaded
with FUCOþGL in rats. In the acute toxicity study, FUCO was fed to rats at doses of 0.1, 1, 10 and 100 mg/kg body
weight (BW). In the sub-acute toxicity study, FUCO was fed at doses of 1 and 10 mg/kg BW for 28 days. In both the
studies, no mortality and abnormalities in gross morphology were observed. Acute toxicity study revealed that the LD50
of FUCO in CS-NGs is higher than 100 mg/kg BW. No postprandial plasma levels of FUCO were detected. However,
fucoxanthinol (FUOH), a hydrolytic metabolite of FUCO was detected in a dose dependent manner (P<0.01).
Compared to the control group(s), no dose-related toxic effects of CS-NGs with FUCOþGL were found in haematological,
histopathological, plasma biochemical indices, etc. The no-observed-adverse-effect level (NOAEL) for CS-NGs
with FUCOþGL in rats was 10 mg/kg/day. To conclude, no apparent adverse effect of CS-NGs with FUCOþGL
demonstrating CS could be a promising polymer matrix for safe delivery of FUCO. This is the first study to demonstrate
the safety assessment of CS-NGs with FUCOþGL.
|
|
| Date |
2015
|
|
| Type |
Article
PeerReviewed |
|
| Format |
pdf
|
|
| Language |
en
|
|
| Identifier |
http://ir.cftri.com/12816/1/Journal%20of%20Biomaterials%20Applications%202015.pdf
Ravi, Hindupur. and Arunkumar, R. and Baskaran, V. (2015) Chitosan-glycolipid nanogels loaded with anti-obese marine carotenoid fucoxanthin: Acute and sub-acute toxicity evaluation in rodent model. Journal of Biomaterials Applications. pp. 1-15. |
|