Zerumbone Ameliorates High Glucose-Induced Reduction in AMPActivated Protein Kinase Phosphorylation in Tubular Kidney Cells.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
View Archive Info| Field | Value | |
| Relation |
http://ir.cftri.com/13131/
http://dx.doi.org/10.1021/acs.jafc.7b02379 |
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| Title |
Zerumbone Ameliorates High Glucose-Induced Reduction in AMPActivated
Protein Kinase Phosphorylation in Tubular Kidney Cells.
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| Creator |
Shrikanth, C. B.
Nandini, C. D. |
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| Subject |
16 Protein Biochemistry
04 Diabetes Mellitus |
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| Description |
AMP-activated protein kinase (AMPK) plays an important role in pathophysiology of diabetes and its
complications. In recent years, its role in kidney as a therapeutic target in ameliorating diabetic kidney damage is receiving
renewed attention. Efforts on identifying AMPK modulators from dietary sources have gained prominence because of the
tremendous potential it harbors. We therefore, examined the effect of a few bioactives on AMPK phosphorylation in kidney
tubular cells. AMPK phosphorylation at Thr172 was reduced (0.42 ± 0.05-fold change compared to the control; p < 0.01 vs
control) after treatment with high glucose (30 mM) for 48 h and restored by zerumbone (1.59 ± 0.20; p < 0.01 vs high glucose)
but not by other tested modulators. Zerumbone also increased the phosphorylation of downstream target of AMPK, the acetyl-
CoA carboxylase (ACC) without affecting the mitochondrial membrane potential and ADP/ATP ratio. Thus, zerumbone could
potentially be explored as a therapeutic agent in bringing about energy homeostasis in diabetes where high glucose suppresses the
AMPK pathway.
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| Date |
2017
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| Type |
Article
PeerReviewed |
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| Format |
pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/13131/1/J.%20Agric.%20Food%20Chem.%202017%2C%2065%2C%209208-9216.pdf
Shrikanth, C. B. and Nandini, C. D. (2017) Zerumbone Ameliorates High Glucose-Induced Reduction in AMPActivated Protein Kinase Phosphorylation in Tubular Kidney Cells. Journal of Agricultural and Food Chemistry, 65. pp. 9208-9216. ISSN 0007-1145 |
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