Oral Supplementation of GABA Containing Rice Flour Alleviate Acrylamide Induced Oxidative Impairments and Neurotoxicity in Mice.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
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http://ir.cftri.com/13301/
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| Title |
Oral Supplementation of GABA Containing Rice Flour Alleviate Acrylamide
Induced Oxidative Impairments and Neurotoxicity in Mice.
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| Creator |
Divyashri, G.
Gokul, K. Dr., Muralidhara Prapulla, S. G. |
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| Subject |
17 Toxicology
01 Rice |
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| Description |
Endogenous antioxidant cycle play a pivotal role in the prevention of damage induced by free radicals. An imbalance between the
production and removal of free radicals and reactive oxygen species (ROS) enhances the rate of oxidative stress. Oxidative stress play
a major role in the development of neurodegerative diseases. Antioxidants are now being looked as a therapeutic agents, as they have
ability to neutralize free radicals. Rice, being the staple food for nearly 50% of world’s population, play a vital role in the concentration
of antioxidants ingested daily. The present study was designed to investigate antioxidative and neuroprotective effect of gammaaminobutyric
acid (GABA) containing fermented rice flour (GFRF) in acrylamide (ACR) acrylamide (ACR) induced oxidative stress
mice model. GFRF contained 750.55 ± 26.03 mg GABA/100g DM under optimized conditions and fermentation enhanced the levels
of antioxidant phenolics in GFRF (unpublished data). ACR administration caused significant oxidative stress as evident by increased
ROS, protein carbonyls, nitric oxide and malondialdehyde levels in cortex and cerebellum clearly suggesting significant oxidative
stress in vivo. Mice supplemented with GFRF orally, diminished oxidative markers, increased the activities of antioxidant enzymes
in cortex and cerebellum brain region with concomitant increase in GABA levels, conferring neuroprotection against ACR induced
oxidative stress. Our data suggest that antioxidative and neuroprotective effects exerted by GFRF are mediated through decreases in
free-radical generation and increases in activities of superoxide dismutase (SOD) and catalase (CAT) in vivo.
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| Date |
2017
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| Type |
Article
PeerReviewed |
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| Format |
pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/13301/1/EC%20Nutrition%208.6%20%282017%29%20191-203.pdf
Divyashri, G. and Gokul, K. and Dr., Muralidhara and Prapulla, S. G. (2017) Oral Supplementation of GABA Containing Rice Flour Alleviate Acrylamide Induced Oxidative Impairments and Neurotoxicity in Mice. EC Nutrition, 8 (6). pp. 191-203. |
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