Solid Lipid Nanoparticle enhances bioavailability of Hydroxycitric acid than microparticle delivery system.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
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| Relation |
http://ir.cftri.com/13354/
http://dx.doi.org/10.1039/x0xx00000x |
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| Title |
Solid Lipid Nanoparticle enhances bioavailability of Hydroxycitric
acid than microparticle delivery system.
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| Creator |
Ezhilarasi, P. N.
Muthukumar, S. P. Anandharamakrishnan, C. |
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| Subject |
07 Food Engineering
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| Description |
Solid lipid nanoparticles (SLN) are most promising delivery system that improves the stability, bioavailability and controlled
release of food bioactive compounds. The delivery of any bioactive compound to targeted sites is directly affected by
particle size and thus nano delivery system has the potential to enhance bioavailability, controlled release of the bioactive
compounds in a greater extent than microencapsulation. However, the effect of different particle size on the
bioavailability of the active compound was less explored. Moreover, nanoencapsulation of hydrophilic compound by SLN
technique was not much studied due to the complexity involved in non-compatibility between the hydrophilic core and
lipophilic wall matrix. Hence, in order to improve efficiency of SLN to load the hydrophilic molecules and to evaluate the
effect of micro and nanoparticles on the bioavailability, HCA, a model hydrophilic compound was nanoencapsulated using
solid lipid nanocarriers. The HCA loaded SLN (327 nm) exhibited encapsulation efficiency of about 57 % and excellent
storage stability with retention of 82 % HCA and 558 nm particle size during 50 days of storage. Moreover, in simulated
gastrointestinal conditions, SLN-HCA exhibited higher gastrointestinal stability (about 88%) of HCA with better retention of
particle size and also shown excellent controlled release of HCA. On comparison of bioavailability , HCA loaded
nanoparticles (SLN-HCA) had 2 fold higher bioavailability than unencapsulated HCA and 1.3 fold higher bioavailability than
the microparticles (SLM-HCA) due to smaller particle size, longer residence time and controlled release of HCA..
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| Date |
2016
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| Type |
Article
PeerReviewed |
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| Format |
pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/13354/1/RSC%20Adv.%2C%202016.pdf
Ezhilarasi, P. N. and Muthukumar, S. P. and Anandharamakrishnan, C. (2016) Solid Lipid Nanoparticle enhances bioavailability of Hydroxycitric acid than microparticle delivery system. RSC Advances, 6. pp. 53784-53793. |
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