Biocompatible lutein-polymer-lipid nanocapsules: Acute and subacute toxicity and bioavailability in mice.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
View Archive Info| Field | Value | |
| Relation |
http://ir.cftri.com/13358/
http://dx.doi.org/10.1016/j.msec.2016.08.029 |
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| Title |
Biocompatible lutein-polymer-lipid nanocapsules: Acute and subacute
toxicity and bioavailability in mice.
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| Creator |
Arunkumar, R.
Ravi, Hindupur. Baskaran, V. |
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| Subject |
14 Carotenoid Chemistry
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| Description |
Lutein-poly-(lactic-co-glycolic acid) (PLGA)-phospholipid (PL) nanocapsules were prepared (henceforth referred
as lutein nanocapsules) and studied for acute, subacute oral toxicity and bioavailability of lutein in mice.
Prior to examining the safety of lutein nanocapsules, particle size, zeta potential, surface morphology and interaction
between lutein, PLGA and PL were studied. In acute study, mice were gavaged with a single dose of lutein
nanocapsules at 0.1, 1, 10 and 100 mg/kg body weight (BW) and examined for 2 weeks,while in subacute study,
daily micewere gavagedwith a dose of 1 and 10 mg/kg BWfor 4weeks. Results revealed that mean size and zeta
value of lutein nanocapsuleswere 140nmand−44mV, respectively. Acute and subacute toxicity studies did not
show any mortality or treatment related adverse effect in clinical observations, ophthalmic examinations, body
and organ weights. No toxicity related findings were observed in hematology, histopathology and other blood
and tissue clinical chemistry parameters. In subacute study, no observed adverse effect level (NOAEL) of lutein
nanocapsules was found to be at a dose of 10 mg/kg BW. Feeding lutein nanocapsules resulted in a significant
(p b 0.01) increase in lutein level in plasma and tissue compared to the control group. Lutein nanocapsules did
not cause toxicity in mice. However, human trials are warranted.
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| Date |
2016
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| Type |
Article
PeerReviewed |
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| Format |
pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/13358/1/Materials%20Science%20and%20Engineering%20C%2069%20%282016%29%201318%E2%80%931327.pdf
Arunkumar, R. and Ravi, Hindupur. and Baskaran, V. (2016) Biocompatible lutein-polymer-lipid nanocapsules: Acute and subacute toxicity and bioavailability in mice. Materials Science and Engineering C, 69. pp. 1318-1327. |
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