Maternal dietary insult and the biosynthesis of protein and RNA in various cellular fractions of the brain of neonatal and 21-day old rat progeny.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
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http://ir.cftri.com/4612/
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| Title |
Maternal dietary insult and the biosynthesis of protein and RNA in various cellular fractions of the brain of neonatal and 21-day old rat progeny.
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| Creator |
Thakur, M. L.
Van, T. T. Radhakrishnamurty, R. Srivastava, U. S. |
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| Subject |
04 Biosynthesis
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| Description |
The effect of maternal dietary insult during the period of gestation (El) and during
the period of growth, gestation and lactation (Eli) on the body, and cellular
growth (DNA, RNA and protein content), protein and RNA synthesis in the brain
and various cellular fractions of the brain of the neonatal (N) and 21-day old (T)
progeny was investigated. It was noted that body and organ weight failed to
increase normally in the N and T progeny of EI and Eli groups as compared to
a well-fed (WF) group. DNA content did not show any change in the N progeny
but was lower in the T progeny of EI and Eli groups. RNA content and protein
content showed lowering to variable degrees in various cellular fractions of N and
T progeny of E1 and EII groups as compared to a WF group. RNA to DNA, and
protein to DNA ratio were lower in most of the cellular fractions whereas organ
weight to DNA ratios was lower in the N progeny and was higher in the T
progeny of EI and EII groups. The content of total nucleotides and amino acids
and their specific activities showed variable responses in the N and T progeny of
E1 and Eli groups. The synthesis of protein was higher in most of cellular
factions of N progeny of E1 group and T progeny of E1 group. The synthesis of
RNA generally was higher in most of the cellular fractions in the N progeny of
E1 group and Eli group and in the T progeny of Eli group and showed variable
responses in the T progeny of E1 group compared to progeny of WF group.
These result indicate the profound effect of maternal dietary insult during the
period of gestation and periods of gestation and lactation on the molecular and
cellular development of brain of neonatal and 21-days-old progeny and also
demonstrate that how these effects on the molecular and cellular development of
brain will be modulated by the changes in the various cellular fractions of the
brain.
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| Date |
1993
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| Type |
Article
PeerReviewed |
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| Format |
pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/4612/1/NUTRITION%20RESEARCH%2C%20Vol.%2013%2C%20pp.%20225-238%2C%201993.pdf
Thakur, M. L. and Van, T. T. and Radhakrishnamurty, R. and Srivastava, U. S. (1993) Maternal dietary insult and the biosynthesis of protein and RNA in various cellular fractions of the brain of neonatal and 21-day old rat progeny. Nutrition Research, 13. pp. 225-238. |
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