Hexachlorocyclohexane-induced testicular dysfunction in rats.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
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http://ir.cftri.com/4317/
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| Title |
Hexachlorocyclohexane-induced testicular dysfunction in rats.
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| Creator |
Shivanandappa, T.
Krishnakumari, M. K. |
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| Subject |
26 Pesticide Chemistry
17 Toxicology |
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| Description |
Weanling male albino rats were fed 100, 750 and 1500 p.p.m. oftechnical HCH for90days. There was
marked testicular atrophy with reduced tubule size and spermatogenetic arrest at 1500 p.p.m. Histochemically,
there was accumulation of cholesterol-positive lipids in the Sertoli cells and the Leydig cells of the atrophied
testis and biochemical estimation revealed significant increase of total lipid and cholesterol contents. Activities
of As 3 0 hydroxysteroid dehydrogenase (A5 3 0 HSDH), 17 p hydroxysteroid dehydrogenase( I7 HSDH)and
glucose-6-phosphate dehydrogenase (G-6-PDH) in the interstitial cells were markedly decreased suggesting
steroidogenic inhibition in the Leydig cells of the atrophied testis due to HCH feeding.
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| Date |
1983
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| Type |
Article
PeerReviewed |
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| Format |
pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/4317/1/Acta%20pharmacol.%20et%20toxicol.%201983%2C%2052%2C%2012-17.pdf
Shivanandappa, T. and Krishnakumari, M. K. (1983) Hexachlorocyclohexane-induced testicular dysfunction in rats. Acta Pharmacologia and Toxicologie, 52. pp. 12-17. |
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