Mechanism of counteraction of aflatoxin toxicity by thymine and folic acid in Bacillus megaterium.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
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http://ir.cftri.com/2694/
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| Title |
Mechanism of counteraction of aflatoxin toxicity by thymine and folic acid in Bacillus megaterium.
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| Creator |
Vishwanath, P.
Basappa, S. C. Sreenivasamurthy, V. |
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| Subject |
04 Fungi
17 Toxicology 10 Food Microorganisms |
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| Description |
Thymine and cytosine as well as the intermediates in pyrimidine biosynthetm
pathway dihydroorotic acid, erotic acid, earbamyl aspartate and 5'-uridine monophosphato
counteracted the toxic effect of aflatoxin in Bacillus megaterium. Folio acid and aminopterin
counteracted the effect even better. The synergistic effect of thymine or 5'-uridlne monophosphate
and relic acid, was synergistic. 2-14C-Thymine, 6-1aC-orotic acid and 14C-formate but not 2-14Curacil,
were incorporated into DNA more in the presence of aflatoxin. These findings indicated
that aflatoxin inhibited the pyrimidine base synthesis which could be overcome to a great extent
by the addition of thymine and folic acid to aflatoxin-treated cells.
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| Date |
1986
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| Type |
Article
PeerReviewed |
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| Format |
pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/2694/1/Folia%20Microbiol.%2031%2C%20272--276%20%281986%29.pdf
Vishwanath, P. and Basappa, S. C. and Sreenivasamurthy, V. (1986) Mechanism of counteraction of aflatoxin toxicity by thymine and folic acid in Bacillus megaterium. Folia Microbiologica, 31 (4). pp. 272-276. |
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