Inhibitory pattern of tissue esterases in rats fed dietary pirimiphos-methyl.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
View Archive Info| Field | Value | |
| Relation |
http://ir.cftri.com/2354/
|
|
| Title |
Inhibitory pattern of tissue esterases in rats fed dietary pirimiphos-methyl.
|
|
| Creator |
Rajini, P. S.
Muralidhara, Dr. Krishnakumari, M. K. |
|
| Subject |
26 Pesticide Chemistry
17 Toxicology |
|
| Description |
Activities of Acetylcholinesterase (AChE) in brain and erythrocytes, pseudocholinesterase (PChE) in plasma and non-specific carboxylesterase (NSE) in brain, liver, plasma and kidney were assayed at weekly intervals in growing male rats fed dietary pirimiphos-methyl at dosages of 1000, and 1500 ppm for a period of 28 days. Significant inhibition of tissue esterases were observed at the end of 7 days at both the dosages and the enzyme activities remained markedly inhibited at subsequent intervals. Activities of all enzymes (excepting Brain AChE) returned to normal levels following a 7-day maintenance on the insecticide-free diet implicating that pirimiphos-methyl induced little or no permanent tissue damage. The results suggest that plasma NSE level may also serve as a sensitive indicator in monitoring OPI exposure.
|
|
| Date |
1989
|
|
| Type |
Article
PeerReviewed |
|
| Format |
pdf
|
|
| Language |
en
|
|
| Identifier |
http://ir.cftri.com/2354/1/J.%20ENVIRON.%20SCI.%20HEALTH%2C%20B24%285%29%2C%20509-524%20%281989%29.pdf
Rajini, P. S. and Muralidhara, Dr. and Krishnakumari, M. K. (1989) Inhibitory pattern of tissue esterases in rats fed dietary pirimiphos-methyl. Journal of Evironmental Science and Health. Part. B, Pesticides, food contaminants, and agricultural wastes, 24 (5). pp. 509-24. ISSN 0360-1234 |
|