Inhibition of monoamine oxidase by the fungicide metalaxyl.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
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http://ir.cftri.com/2360/
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| Title |
Inhibition of monoamine oxidase by the fungicide metalaxyl.
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| Creator |
Naidu, K. A.
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| Subject |
26 Pesticide Chemistry
17 Toxicology |
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| Description |
The in vitro effect of metalaxyl on monoamine oxidase (MAO) activity in rat heart was studied. Metalaxyl decreased MAO activity in a dose-dependent manner. The inhibitory concentration (IC50) for metalaxyl was found to be 19 mumol. Substrate-dependent kinetic studies demonstrated noncompetitive inhibition as evidenced by decreased velocity of enzyme activity (Vmax) without significant change in enzyme-substrate affinity (Km). The inhibition of MAO activity by metalaxyl suggests interference with amine metabolism.
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| Date |
1989
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| Type |
Article
PeerReviewed |
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| Format |
pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/2360/1/Journal%20of%20Toxicology%20and%20Environmental%20Health%2C%2027395-398%2C%201989.pdf
Naidu, K. A. (1989) Inhibition of monoamine oxidase by the fungicide metalaxyl. Journal of Toxicology and Environmental Health, 27 (3). pp. 395-8. ISSN 0098-4108 |
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